Boris Johnson and Health Secretary Matt Hancock have both tested positive for coronavirus.
The Prime Minister said he had developed mild symptoms, including a temperature and persistent cough, over the last 24 hours and is now self-isolating.
But he added that he "will continue to lead the government’s response" via video-conference.
In a video message posted on Twitter, he said working from home and self-isolating was "entirely the right thing to do".
He added: "But, be in no doubt that I can continue, thanks to the wizardry of modern technology, to communicate with all my top team to lead the fightback against coronavirus."
Mr Hancock has also shared a video message online he said: "Following medical advice, I was advised to test for #Coronavirus.
"I‘ve tested positive. Thankfully my symptoms are mild and I’m working from home & self-isolating."
WATCH: Matt Hancock says he will continue workign to fight coronavirus after testing positive
From his home he added: "I will be continuing to do everything I can to get our carers the support that they need and I'll be doing that from here but with no less gusto."
While the Prime Minister insists that he will continue to work from home, it is understood that should he become too unwell to do so, Foreign Secretary Dominic Raab will step in.
A number of politicians took to Twitter to wish the Prime Minister a full recovery.
Shadow home secretary Diane Abbott tweeted: "I don't wish anyone ill. I wish the Prime Minister a speedy recovery. I hope everyone in coming days gets the care and medical attention they need."
Nigel Farage posted: "Wishing @BorisJohnson well and a very rapid recovery."
And former chancellor Sajid Javid replied: "Get well soon. Sending you best wishes from Javid family and Bailey."
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