Parliament has authorised Theresa May to trigger Article 50 after the Lords amendments to the official withdrawal bill were voted down.
The European Union (Notification of Withdrawal) Bill had received two amendments during its passage through the Lords, one to protect the rights of EU nationals and the other to guarantee a final Commons vote on the deal negotiated with Brussels.
However MPs voted to reject the two amends, by almost identical margins, and the Lords then declined the opportunity to reinsert the changes.
The bill has now cleared Parliament, allowing Theresa May to begin formal Brexit negotiations once the bill receives royal assent to become an Act of law.
The Brexit Secretary, David Davis, praised the outcome. He said the United Kingdom was now "on the threshold of the most important negotiation for our country in a generation."
Meanwhile, Downing Street has reaffirmed the Prime Minister won't invoke Article 50 until the end of March.
A spokesman said: "I've said 'end' many times but it would seem I didn't put it in capital letters strongly enough."