Daniel Hannan has warned that if the Labour Party "get their way" on holding a second referendum the results could be "catastrophic".
The Conservative MEP appeared on the breakfast show to discuss Jeremy Corbyn's announcement that his party would push for a second vote if his Brexit demands are not met.
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"It'll be a choice between remain in all but name, or remaining in name and the victory that was won by the largest number of British people who have ever voted for anything will be taken off the ballot paper," Hannan told Julia Hartley-Brewer.
"So there won't be a meaningful referendum if they get their way."
Hannan, himself a leave campaigner, added: "Labour will do anything for the working man except ask his opinion."
Daniel Hannan pictured in Washington D.C. Image: Gage Skidmore
Announcing his support for a second referendum, Labour leader Corbyn said he would do "everything" in his power to avoid a "damaging Tory Brexit".
However, Hannan said overturning the result of the 2016 referendum could result in a "complete redrawing" of the political system.
"They will ceased to be believed on anything, both Conservative and Labour parties," he warned. "The impact both on the legitimacy of our Parliamentary consititutions and the appeal of our traditional parties will be absolutely calamitous."
"I think we could be looking at a complete redrawing of the British party system."