The decision to close the iconic Fabric nightclub has been criticised by London Mayor Sadiq Khan.
Khan warned of the decline of the city's nightlife and said he was "disappointed" that Fabric nightclub, Islington Council and the Metropolitan Police had failed to reach an agreement
The council revoked the Farringdon venue's licence in the early hours of Wednesday, after finding it had a "culture of drug use" which staff were "incapable of controlling".
The decision has been labelled "archaic" and "a devastating blow for London" bykey music industry figures.
The club closed temporarily after the deaths of two teenagers from suspected drug overdoses earlier this year, and last month the Met applied to the council for the licence to be reviewed.
Mr Khan said: "London's iconic clubs are an essential part of our cultural landscape.
"Clubbing needs to be safe but I'm disappointed that Fabric, Islington Council and the Metropolitan Police were unable to reach agreement on how to address concerns about public safety.
"As a result of this decision, thousands of people who enjoyed going to Fabric as an essential part of London's nightlife will lose out."