George Galloway opened his show on Friday with a angry monologue in light of the Grenfell Tower fire.
The death toll from the fire has now reached 79, but it is still thought that number could rise and operations at the tower block continue.
Speaking before the death toll had risen to this level, Galloway said: "I don’t need a public inquiry to tell me that whoever signed off the deal to save £2 per square metre on flammable cladding rather than inflammable cladding is guilty of manslaughter.
"I want arrests and I want prosecutions, I want to know who made that decision and why they made it."
Galloway continued by saying "the people responsible for this are responsible for manslaughter, corporate manslaughter and they should go to prison for a very long time."
He also criticised Boris Johnson, saying he wants to know why the then London mayor didn't realise that "whatever saving he made by closing these fire stations [in London], wrecking these [firefighting] appliances, sacking these firefighters, might not have to be paid for by something much more valuable than gold, paid for in human blood."
The talkRADIO presenter called for Theresa May to leave her position, saying. "We have a Prime Minister so bereft of moral, political and parliamentary standing, that she is forced to go cap in hand to the bigots of the orange order and the so-called democratic, so-called unionist party in order to form a government. A Prime Minister who called an unnecessary election.
"I want to know how long this miserable wretched government with no majority...I want to know how long they are going to sit there, how long are you going to sit there Theresa May for all the good that you have been doing, in the name of God go."
Listen to the full audio above