George Galloway's opening monologue saw him issue a challenge to Jacob Rees-Mogg.
Rees-Mogg has been tipped by a number of bookies to become the next leader of the Conservative Party.
Last week, he made headlines after admitting on ITV's Good Morning Britain he was opposed to abortion "in all circumstances" and was also opposed to gay marriage.
Despite being unable to entice him onto The Mother of all Talk Shows, George said he was ready for a "principled dust-up" with the MP for North East Somerset over this point.
He said: "Jacob, if you’re listening – as I know you are, or will be – how come guys like you are so concerned about the fate of unborn children but don’t give a toss about children already born?
“You don’t give much of a toss about our own children born into poverty and live lives of stunted opportunity as a result and go on to live a life you couldn’t conceive of.
"How come guys like you - and your counterparts on the evangelical wing in the United States - care so much about the lives of unborn children, but don’t give a toss when children that are born die on floating coffins crossing the Mediterranean desperately as refugees or swimming the Rio Grande on the back of their parents trying to get in?
"Build a wall, won’t you, to keep them out, but do tell us how piously you pray for the safe conduct and keeping of the unborn.
"Hypocrites – I’m sorry, most of you are. I happened to care about the fate of unborn child and those already born just as equally."