Kabul was flooded with protesters calling for the resignation of Ashraf Ghani on Friday in the wake of the blast which killed more than 80 people and injured hundreds.
Security forces were forced to fire rounds into the air in order to disperse the throng of demonstrators which filled the streets.
There were close to 1,000 protestors at the site of the bombing itself, claiming Ghani and his government were responsible for it.
The large group also demanded that members of a jihadist group - the Haqqani network, linked to the Taliban - be executed.
There are no reported casualties from police fire.