Jacob Rees-Mogg has said a second referendum would not provide a "solution" to Brexit.
The Conservative politician said suggestions by Labour leader Jeremy Corbyn that he would back another vote in order to avoid a no-deal Brexit would not "put the issue to bed".
"Hardline remainers would ask for a third referendum if they lost again, whereas if our side lost we would think that the first referendum was more important," Rees-Mogg told talkRADIO's Julia Hartley-Brewer.
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"A referendum is no solution."
He added: "A referendum has been held, 17.4 million voted to leave, Parliament said it would accept the result, the Labour Party and the Conservative Party in their manifestos in 2017 said they would accept the result. That is what must happen."
'Cards have been poorly played'
Theresa May with European Commission president Jean-Claude Juncker
The politician added that it was a "mistake" to have a remain-backing politician lead negotiations with the EU, adding that "the cards have been poorly played".
When asked by Julia whether another Prime Minister could have secured a better deal, Rees-Mogg replied: "Unquestionably".
"It was a mistake to have somebody who backed remain leading the negotiations, because the negotiations have tried to maintain as much of the EU as possible, whereas the advantage of voting to leave was to get rid of as much of the EU as possible."