Owen Paterson has announced his support for a coup against the Prime Minister.
The former Northern Ireland secretary called for both a new leader and a new cabinet, after Mrs May's announcement that she would let MPs vote on whether to have a second referendum if they supported her Withdrawal Agreement Bill.
There are rumours that an attempted coup will take place against the Prime Minister, with the 1922 Committee of backbenchers reportedly meeting later today in a bid to eject her from Downing Street.
Mr Paterson said he "very much" hoped that the coup would go ahead.
"This can't go on," he told talkRADIO's Julia Hartley-Brewer. "We need a new Prime Minister and we need a new cabinet."
"The last promise she made is that we won't have a second referendum and now she has broken that. She has broken every single promise which we made solemnly to the British people in a general election. That's why people don't trust us."
He added: "Every Monday morning I come down thinking it can't get worse and it has."
The deal has received a hostile response from Conservative MPs, prompting the Prime Minister to write a letter to Labour leader Jeremy Corbyn in an effort to garner support for it.
But Mr Paterson insisted the deal was "not going to get through" the Commons.
"Jeremy Corbyn has said clearly they are not going to support it. So we have to have a fresh start and stick to that target of October 31," he said.
"There's a lot of hysterical, remainer project fear nonsense about no deal," he said.
"There's not going to be a no deal, there will be World Trade terms with side deals."