Leave-supporting Stephen Barclay has been promoted to Brexit Secretary from a ministerial role in the Department for Health.
In a further reduction to the Brexit Secretary's duties, it was revealed that Theresa May will in future take sole control of negotiations on EU withdrawal.
Mr Barclay's job will be limited to the domestic delivery of EU withdrawal, preparations for Brexit either with or without a deal and shepherding legislation through Parliament.
Downing Street declined to say whether the Brexit Secretary post had been offered to anyone else before the North-East Cambridgeshire MP, saying only: "He was the Prime Minister's choice for the job."
Following the resignation of Dominic Raab and Esther McVey over Mrs May’s proposed EU Withdrawal Agreement, Amber Rudd was offered a return to the Cabinet in the role of Work and Pensions Secretary.