With the plans to change the boundaries of consituencies in play for 2020, reducing the size of Parliament from 650 to 600 MPs, a host of the biggest beasts in the political jungle could lose their seats, or be forced to fight for new ones.
One of the most intruguing sub-plots is in north London, where the proposed changes could bring Jeremy Corbyn into conflict with two of his closest political allies.
But Labour isn't the only party affected by the changes. Indeed two of the leading campaigners for Brexit, Boris Johnson and Douglas Carswell, could also be forced to campaign on fresh ground - a prospect which neither will be particularly relishing.
Check out the gallery above to see the high-profile politicians who are affected by the Boundary Commission's plans.